Conservation Coiled-coil domain containing 42B

1 conservation

1.1 paralogs
1.2 orthologs
1.3 phylogeny

conservation

the basic alignment search tool (blast) of human ccdc42b protein-to-protein database including mammalia closely related species, , excluded mammalia distantly related species resulted in several orthologs species reasonable e-value, , high, medium , low coverage depending on relatedness of orthologs human ccdc42b. higher conservation of ccdc42b gene resulted in several strict orthologs (mammalian) of percentage identity range of 95%-53%: rhesus monkey, whale, pig, cattle, , mouse. lower conservation of ccdc42b gene in distant homologs (non-mammalian) of percentage identity range of 23%-40%: drosophila, reptile, amphibians , fish.

paralogs

ccdc42b gene has 1 major paralogs ccdc42 (ccdc42a)

orthologs

human ccdc42b gene found in ~58 orthologs species. ccdc42b higher conservation in many mammalian orthologs species compared non-mammalian orthologs species. higher conservation of ccdc42b gene in several strict orthologs (mammalian): chimpanzee, rhesus monkey, dog,cow, mouse, rat , chicken, , identities range between 95%-69%. lower conservation of ccdc42b gene in distant homologs (non-mammalian): birds, reptile, amphibians , fish , identities range between 23%-40%. figure shows comparison between strict orthologs , distant homologs conservation of ccdc42b (purple color: matched amino acid residues ; blue: conserved residues ; pink: similar residues ; white: different residues )

strict orthologs vs. distant homologs ccdc42b.



phylogeny

according biology workbench, phylogenetic tree constructed showing divergent of ccdc42b across species.the percent identity vs. divergent time of orthologs species compared human sequence shown below. figure illustrates evolutionary history of ccdc42b gene in various species (shown in orthologs space). closely related species has higher percent identity, provides statistical evidence higher amino acids conservation.distantly related species human ccdc42b showed lower percent identity, supports few conservation of amino acid residue. figure highlights amount of changes occurred in ccdc42b evolution , rate of mutation in gene.