Visual prosthesis Neurostimulation



the visual cortical implant


theoretical , experimental clinical evidences suggest direct electrical stimulation of retina might able provide vision subjects have lost photoreceptive elements of retina. therefore, visual prostheses developed restore vision blind using stimulation. depending upon visual pathway location targeted neural stimulation, different approaches have been considered. visual pathway consists of eye, optic nerve, lateral geniculate nucleus (lgn), , visual cortex. therefore, retinal, optic nerve , visual cortex stimulation 3 different methods used in visual prostheses. retinal degenerative diseases, such retinitis pigmentosa (rp) , age-related macular degeneration (amd), 2 candidate diseases in retinal stimulation may helpful. 3 approaches called intraocular epiretinal, subretinal , extraocular transretinal stimulation pursued in retinal devices stimulate remaining retinal neural cells bypass lost photoreceptors , allow visual signal reach brain via normal visual pathway. in epiretinal approach, electrodes placed on top side of retina near ganglion cells, whereas electrodes placed under retina in subretinal approaches. finally, posterior scleral surface of eye place in extraocular approach electrodes positioned. second sight , humayun group @ usc active groups in design of intraocular retinal prostheses. argustm 16 retinal implant intraocular retinal prosthesis utilizing video processing technologies. regarding visual cortex stimulation, brindley, , dobelle first ones did experiments , demonstrated stimulating top side of visual cortex of electrodes can produce visual percept. more sawan built complete implant intracortical stimulation , validated operation in rats



a pacemaker, scale in centimeters


lgn, located in midbrain relay signals retina visual cortex, potential area can used stimulation. area has limited access due surgical difficulty. recent success of deep brain stimulation techniques targeting midbrain has encouraged research pursue approach of lgn stimulation visual prosthesis.








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