Applications Tsuji–Trost reaction

another tsuji–trost reaction used during initial stages of synthesis of (−)-neothiobinupharidine. recent work demonstrates ability of reaction give highly diastereoselective (10:1) , enantioselective (97.5:2.5) products achiral starting material small amount of catalyst (1%).

palladium detection

aside practical application of reaction in medicinal chemistry , natural product synthesis, recent work has used tsuji–trost reaction detect palladium in various systems. detection system based on non-fluorescent fluorescein-derived sensor (longer-wavelength sensors have been developed other applications) becomes fluorescent in presence of palladium or platinum. palladium/platinum sensing ability driven tsuji–trost reaction. sensor contains allyl group fluorescein functioning leaving group. π-allyl complex formed , after nucleophile attacks, fluorescein released, yielding dramatic increase in fluorescence.

this simple, high-throughput method detect palladium monitoring fluorescence has been shown useful in monitoring palladium levels in metal ores, pharmaceutical products, , in living cells. ever-increasing popularity of palladium catalysis, type of quick detection should useful in reducing contamination of pharmaceutical products , preventing pollution of environment palladium , platinum.