Alleles HLA-DQ1

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1 alleles

1.1 dqa1*0101
1.2 dqa1*0102
1.3 dqa1*0103
1.4 dqa1*0104





alleles
dqa1*0101

dqa1*0101 commonly linked haplotypes of dqb1*05, common dqa1*0101:dqb1*0501 haplotype part of broader dr1-dq1 haplotype.


dqa1*0102

dqa1*0102 associated both dr5 , dr6.


dqa1*0102:dqb1*0502 has bimodal distribution. found in philippines in high frequency , on mediterranean island of sardinia.


dqa1*0102:dqb1*0602 common haplotype in eurasia, higher frequency in central asia relative elsewhere. part of european ancestral haplotype b7-dr15-dq1 appears have expanded asymmetrically europe. a3-b7-dr15-dq1 haplotype indicates relationships in eurasia span korea ireland, indicating common ancestry in recent times.


dqa1*0102:dqb1*0604 less found spread widely.


dqa1*0103

dqa1*0103 (*0103) shows negative (protective) association many autoimmune disease, association apparent in japanese studies in *0103:dqb1*0601 haplotype, , in europe *0103:dqb1*0603 haplotype, indicating protective effect influenced alpha chain of dq. dqa1*0103 protective against behçet s disease, pemphigus vulgaris, juvenile diabetes, steroid-sensitive nephrotic syndrome, myasthenia gravis coeliac disease multiple sclerosis, chronic active hepatitis c, , vogt-koyanagi-harada syndrome. however, may predispose carriers chronic infection such leprosy, helicobacter pylori-positive gastric lymphoma, , aids.


dqa1*0103:dqb1*0601 part of multigene haplotype (drb1*1502:drb5*0102:dqa1*0103:dqb1*0601:dpa1*02:dpb1*0901) linked takayasu arteritis in japanese. haplotype, dr8-dq1 contains haplotype may associated primary biliary cirrhosis, grave s disease there negative association of dr15-dq1 haplotype in japanese inflammatory bowel disease.


dqa1*0103:dqb1*0603 part of dr-dq haplotype (dr13-dq1) increases primary sclerosing cholangitis same haplotype shows negative association rheumatic heart disease,


dqa1*0104

dqa1*0104:dqb1*0503 part of multigene haplotype dr14-dq5 associated musk positive myasthenia gravis.








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