History Tsuji–Trost reaction

the scope of reaction expanded gradually until trost discovered next big breakthrough in 1973. while attempting synthesize acyclic sesquiterpene homologs, trost ran problems initial procedure , not able alkylate substrates. these problems overcome addition of triphenylphosphine reaction mixture.

these conditions tested out other substrates , led instantaneous reaction @ room temperature. after, developed way use these ligands asymmetric synthesis. not surprisingly, spurred on many other investigations of reaction , has led important role reaction holds in synthetic chemistry.