Receptor oligomerization G protein–coupled receptor

g-protein-coupled receptor oligomerisation widespread phenomenon. 1 of best-studied examples metabotropic gabab receptor. so-called constitutive receptor formed heterodimerization of gababr1 , gababr2 subunits. expression of gababr1 without gababr2 in heterologous systems leads retention of subunit in endoplasmic reticulum. expression of gababr2 subunit alone, meanwhile, leads surface expression of subunit, although no functional activity (i.e., receptor not bind agonist , cannot initiate response following exposure agonist). expression of 2 subunits leads plasma membrane expression of functional receptor. has been shown gababr2 binding gababr1 causes masking of retention signal of functional receptors.